While helping lost souls to get reborn, the spirit Gudo meets a girl called Yuri. He embarks on a 1,000-year journey to help her through her various incarnations to remove her Seed of Evil, a kernel within her that turns her into a monstrous Wrath if she gets consumed by anger. He learns that helping her find self-forgiveness for the tragic loss of her brother is the only way to save her. (From Annecy film festival's website)